Serum HGF ,PCIII and PLT are Noninvasive Markers for the diagnosis of nonalcoholic fatty liver disease

Abstract

Abstract Background/Aims: It was suggested that serum HGF,PCIII and PLT play important roles in nonalcoholic fatty liver disease (NAFLD). Thus, we aimed to evaluate their clinical utility in the diagnosis of patients with suspected NAFLD.Methods:300 Patients with NAFLD were compared to 102 matched controls.All were subjected to history taking, anthropometric measurements, and abdominal ultrasonography, as well as laboratory assessments of liver functions, fasting lipid profile, GLU, serum PLT, HGF and PCIII.Results:The levels of HGF,PCIII and PLT were higher in NAFLD cases than controls ,and with progressive increases as the severity of fatty liver increased（P<0.05）.HGF,PCIII and PLT were correlated with various clinical parameters and severity of NAFLD（P<0.05）.The optimal cut-off values for HGF in diagnosis of mild, moderate and severe fatty liver were 14.1pg/ml(AUROC 0.753,P＝0.004), 15.4pg/ml(AUROC 0.836, P < 0.001), 17.7pg/ml(AUROC 0.903, P < 0.001). PCIII had no value in differentiate mild from moderate fatty liver ,but its ability to diagnose severe fatty liver was significant. A cut-off value for PCIII to diagnose severe fatty liver was 7.9ng/L(AUROC 0.773).The optimal cut-off values for PLT in the diagnosis of mild, moderate and severe fatty liver were 194×10^9/L(AUROC 0.732), 195×10^9/L(AUROC 0.765), 200×10^9/L(AUROC 0.925), respectively with P < 0.001. When three indicators were tested together,the AUROC(95%CI)curve for diagnose NAFLD was 0.881(sensitivity0.760,specificity 0.873)(P<0.001) .Conclusion:.Combined detection of serum HGF, PCIII and PLT may be an effective non-invasive method for diagnosing NAFLD.