Synthesis of novel phthalimido oxime pseudoesters and evaluation of their cytotoxicity

Abstract

A series of novel optically pure oxime pseudoesters derivatives were synthesized by the reaction of substitute keto oximes with various N-substituted ?-amino acids chlorides in the presence of triethylamine and dichloromethane at 0?C, and their structures were characterized by IR and 1D-NMR methods. The synthesized compounds were tested for their ability to inhibit the proliferation of human colon cancer cells and human epithelial cells. Some of them were revealed to have a significant cytotoxic effect.