Affiliation:
1. Klinički centar Niš, Klinika za plućne bolesti i tuberkulozu, Niš
2. Klinički centar Niš, Centar za medicinsku biohemiju, Niš
Abstract
Introduction. A lot of studies have dealt with the oxidative stress in
pulmonary diseases, and some of them with tuberculosis as well. The aim of
this study was to examine the antioxidant enzyme level (superoxide dismutase,
glutathione peroxidase, catalase) and the lipid peroxidation products in
patients with tuberculosis. Material and methods. Forty patients with
tuberculosis were included in the study. The examined parameters were
measured before and three weeks after the beginning of the antituberculosis
treatment (group I). The control group included 40 healthy persons (group
II). Results. The superoxide dismutase level was significantly lower in group
I in both measurements (p<0.001 and p<0.01) in relation to group II, but
there were no significant changes in its level during the therapy. During the
treatment, the glutation peroxidase level significantly increased (p<0.05),
and in relation to group II, its level was significantly lower in both
measurements in group I (p<0.001 and p<0.001). The catalase level
significantly increased during the treatment, but there was no significant
difference in relation to group II level. There was no significant difference
in relation to the lipid peroxidase products between the groups. Discussion.
Our study group had reduced antioxidant enzyme level and some of them showed
significant improvement during the treatment. The lipid peroxidase product
level was stable. Conclusion. In patients with tuberculosis the antioxidative
status is lower and its level and possible development of the oxidative
stress depend on the disease severity.
Publisher
National Library of Serbia
Cited by
9 articles.
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