Metabolism of the mother, placenta and fetus in diabetes-Reference-Cited by-同舟云学术

Metabolism of the mother, placenta and fetus in diabetes

Published:2023 Issue:1-2 Volume:151 Page:116-119
ISSN:0370-8179
Container-title:Srpski arhiv za celokupno lekarstvo
language:en
Short-container-title:Srp Arh Celok Lek

Author:

Dugalic Stefan¹^ORCID,Todorovic Jovana²,Macura Maja¹^ORCID,Gutic Bojana³,Milincic Milos⁴,Bozic Dragana⁵,Stojiljkovic Milica⁶,Petronijevic Milica⁷,de Luka⁸^ORCID,Pantic Igor⁹^ORCID,Perovic Milan¹⁰^ORCID,Parapid Biljana¹¹^ORCID,Gojnic Miroslava¹^ORCID

Affiliation:

1. University Clinical Centre of Serbia, Clinic for Gynecology and Obstetrics, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, Serbia

2. University of Belgrade, Faculty of Medicine, Institute of Social Medicine, Belgrade, Serbia

3. University of Novi Sad, Institute of Oncology of Vojvodina, Clinic for Operative Oncology, Novi Sad, Serbia

4. University of Belgrade, Faculty of Medicine, Institute of Medical Statics and Informatics, Belgrade, Serbia

5. University Clinical Centre of Serbia, Clinic for Gynecology and Obstetrics, Belgrade, Serbia

6. University of Belgrade, Faculty of Medicine, Belgrade, Serbia + University Clinical Centre of Serbia, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Belgrade, Serbia

7. University of Belgrade, Faculty of Medicine, Belgrade, Serbia

8. University of Belgrade, Faculty of Medicine, Institute for Medical Pathophysiology, Belgrade, Serbia

9. University of Belgrade, Faculty of Medicine, Institute of Medical Physiology, Belgrade, Serbia

10. University of Belgrade, Faculty of Medicine, Belgrade, Serbia + Narodni Front University Clinic for Gynecology and Obstetrics, Belgrade, Serbia

11. University of Belgrade, Faculty of Medicine, Belgrade, Serbia + University Clinical Centre of Serbia, Division of Cardiology, Belgrade, Serbia

Abstract

Metabolic changes occur due to the effects of placental hormones such as human chorionic gonadotropin and human placental lactogen in normal pregnancies. These effects enable the development of insulin resistance among all pregnant women, significantly pronounced in the third trimester. In pregnancies complicated by pre-gestational or gestational diabetes mellitus, these changes are more intensive as they affect the fetoplacental unit. In pregnancies complicated by diabetes the increased number of placental macrophages leads to the increased production of different cytokines which include leptin, tumor necrosis factor alpha, and interleukins. This review addresses placental vascular changes that lead to adverse pregnancy outcomes, along with the effects of the maternal hyperglycemia and fetal hyperinsulinemia.

Publisher

National Library of Serbia

Subject

General Medicine

Reference20 articles.

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