Affiliation:
1. Faculty of Technical Science, Kosovska Mitrovica
2. Faculty of Technology and Metallurgy, Belgrade
3. Institute of Nuclear Sciences Vinča, Laboratory for Material Science, Belgrade
Abstract
The present study reports the new facile methodology for synthesis of
symmetrical and asymmetrical thioureas by an one-pot reaction of amine,
carbon disulfide and oxidants: hydrogen peroxide, ethylenediamine tetraacetic
acid (EDTA)/sodium percarbonate system or air. The structures of the
synthesized compounds were confirmed by IR, 1H and 13C NMR and MS methods.
Reaction mechanism has been proposed on the basis of reaction intermediate
isolation and their structure determination. The synthetic benefits of the
presented methods is reflected in the operational simplicity, mild reaction
conditions, short reaction times, recycling of solvent, high purity and yield
of products, absence of dangerous by-products and technological applicability
at industrial scale. Considering commercial importance of the thioureas, it
can be emphasized that implementation of the optimal synthesis of thiourea,
based on presented methods, at industrial level of production would provide
concurrent alternative to existing technologies in use.
Funder
Ministry of Education, Science and Technological Development of the Republic of Serbia
Publisher
National Library of Serbia
Cited by
7 articles.
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