Thermoanalytical and spectroscopic studies on medicated jellies with perphenazine

Abstract

Medicated jellies are widely used by a large part of patients, especially by people with swallowing difficulties. Preformulation studies play an essential role in the development of new pharmaceutical formulations. The present study aimed to formulate and evaluate medicated jellies containing perphenazine, an antipsychotic drug from the group of phenothiazine compounds used to treat schizophrenia and other mental disorders. Typical gelling agents such as sodium alginate (Alg), gelatine (Gel), and pectin (Pec) were used to develop the medicated jellies. In addition to the biopolymers, components such as benzoic acid (BenzAc), citric acid (CitAc), sodium citrate (NaCit), sorbitol (Sorb), and xylitol (Xyl) were also used. Before preparing the jellies, the moist binary mixture between each component of the jelly and the active substance was analyzed to investigate the compatibility of the substances. The active substance, moist binary mixture, and medicated jellies were analyzed by FTIR_UATR spectroscopy, UV-Vis spectroscopy, and thermogravimetry (TGA).