Correlation between p53 expression and clinical-pathological characteristics of gastric cancer

Abstract

Backgraund/Aim. Gene p53, or ?cell genome keeper?, has a preventive effect on the occurrence of genetic aberrations and prevents abnormal expansion of (tumor) cells. In gastric cancer cells in most cases we register high expression of mutated p53 gene, which correlates with prognosis and specific clinicalpathological characteristics of gastric cancer. Methods. Using the imunohistochemical method we determined the level of expression of p53 protein in 62 gastric cancers and 30 precancerous conditions (intestinal metaplasia of the stomach). We analyzed the relationship of the level of p53 expression and clinical pathological characteristics of gastric cancer. Results. Expression of p53 was positive in 42 (67.7%) tumor cases and in 7 (14.3%) cases of intestinal metaplasia. Expression of P53 and stomach cancer were in direct correlation (p = 0.000). Sensitivity for p53 in stomach cancer cases was 67.7% (42/62), and specifility was 76.7% (23/30). Expression of mutated p53 protein was in direct correlation with the invasion of lymph nodes (p = 0.034) and with invasion of blood vessels by carcinoma cells (p = 0.042). Conclusion. There is a direct correlation between p53 expression and gastric cancer and it indicates the ability of carcinoma cells to invade blood vessels.