Affiliation:
1. Stavropol State Agrarian University, Faculty of Veterinary Medicine, Stavropol, Russian Federation
2. Stavropol Research Anti-plague Institute, Stavropol, Russian Federation
3. All-Russian Research Institute of Sheep and Goat Breeding, Stavropol, Russian Federation
4. Institute for Animal Husbandry, Belgrade
Abstract
One of the new promising candidate genes defining productive qualities of
sheep is MEF2B. Protein from the MEF2 group encoded by it affects the
production of myostatin and the expression of the genes responsible for the
growth of skeletal muscle fibers. Thus, the knowledge of the MEF2B gene
structure is important for genomic selection. We have studied the structure
of the MEF2B gene at sheep of Severokavkazskaya breed bred in Russia. To
detect alleles we use NimbleGen sequencing technology by Roche (USA). As a
result, it was revealed 14 single nucleotide polymorphisms (SNP) at the
given breed. The discovered SNPare located in not coding areas. From them 7
polymorphisms are in the area of 5? upstream gene in loci: c.-1713, c.-1319,
c.-839, c.-321, c.-246, c.-161, c.-3; 6 polymorphisms are in introns, loci:
c.55-51, c.258+312, c.258+380, c.259-52, c.452+95, c.452+103, 1 SNP is in 3?
downstream gene, c.
Publisher
National Library of Serbia
Cited by
5 articles.
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