Affiliation:
1. Institut za zdravstvenu zaštitu dece i omladine Vojvodine, Novi Sad + Medicinski fakultet, Novi Sad
Abstract
Growth is a complex process and the basic characteristic of child- hood
growth monitoring provides insight into the physiological and pathological
events in the body. Statistically, the short stature means departure from the
values of height for age and sex (in a particular environment), which is
below -2 standard deviation score, or less than -2 standard deviation, i.e.
below the third percentile. Advances in molecular genetics have contributed
to the improvement of diagnostics in endocrinology. Analysis of patients?
genotypes should not be performed before taking a classical history, detailed
clinical examination and appropriate tests. In patients with idiopathic short
stature specific causes are excluded, such as growth hormone deficiency,
Turner syndrome, short stature due to low birth weight, intrauterine growth
retardation, small for gestational age, dysmorphology syndromes and chronic
childhood diseases. The exclusion of abovementioned conditions leaves a large
number of children with short stature whose etiology includes patients with
genetic short stature or familial short stature and those who are low in
relation to genetic potential, and who could also have some unrecognized
endocrine defect. Idiopathic short stature represents a short stature of
unknown cause of heterogeneous etiology, and is characterized by a normal
response of growth hormone during stimulation tests (>10 ng/ml or 20 mJ/l),
without other disorders, of normal body mass and length at birth. In
idiopathic short stature standard deviation score rates <-2.25 (-2 to -3) or
<1.2 percentile. These are also criteria for the initiation of growth hormone
therapy. In children with short stature there is also the presence of
psychological and social suffering. Goals of treatment with growth hormone
involve achieving normal height and normal growth rate during childhood.
Publisher
National Library of Serbia
Cited by
2 articles.
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