Synthesis, thermal and antitumour studies of Th(IV) complexes with furan-2-aldehyde-N-phenyl thiosemicarbazone

Abstract

Thorium(IV) complexes with the Schiff base furan-2-aldehyde-N-phenyl thiosemicarbazone (L) were synthesised and characterized. The composition and structure of the metal complexes were proposed base on elemental analysis, molar conductivity measurements, FTIR and 1H-NMR spectroscopy. The Schiff base behaves as a neutral bidentate ligand coordinating through the azomethine N and the thioketo S atoms. From various studies, complexes were ascertained the general formula [ThL2X4] and [ThL2Y2] where X represents the monovalent anions NO3-, NCS-, CH3COO-, CH3CHOHCOO-, ClO4-,and Y the bivalent anions SO4 2-and C2O4 2-. The thermal behaviour of the nitrato and oxalato complexes was studied and kinetic and thermodynamic parameters were calculated using the Coats-Redfern Equation. The ligand and a representative complex [ThL2(NO3)4] were screened in vitro for their antitumour activity against the human cervical cancer cell line (Hela).