Affiliation:
1. Faculty of Agriculture, Belgrade
2. Institute of Chemistry, Tehnology and Metallurgy, Department of Chemistry, Belgrade
3. Institute of Oncology and Radiology, Belgrade
4. Faculty of Science, Institute of Chemistry, Kragujevac
5. Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany
6. Faculty of Chemistry, Belgrade
Abstract
Novel (S,S)-R2eddip ester,
O,O?-diisoamyl-(S,S)-ethylenediamine-N,N?-di-2-propanoate dihydrochloride,
1, was synthesized and characterized by IR, 1H and 13C NMR spectroscopy,
mass spectroscopy and elemental analysis.In vitro antitumor action of 1, and
two more R2eddip esters,
O,O?-dialkyl-(S,S)-ethylenediamine-N,N?-di-2-propanoate dihydrochlorides,
obtained before, (alkyl = n-Bu, n-Pe; 2 and 3, respectively), was determined
against cervix adenocarcinoma (HeLa), human melanoma (Fem-x), human chronic
myelogenous leukemia (K562) cells, and a non-cancerous cell line human
embryonic lung fibroblast (MRC-5), using MTT assay. Esters 1-3 showed higher
cytotoxicity and better selectivity in comparison to cisplatin, used as
reference compound. The highest activityis expressed by1,with
IC50(Fem-x)value1.51 ? 0.09 ?M.
Funder
Ministry of Education, Science and Technological Development of the Republic of Serbia
Publisher
National Library of Serbia
Cited by
6 articles.
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