Hydantoins: Synthesis, properties and anticonvulsant activity-Reference-Cited by-同舟云学术

Hydantoins: Synthesis, properties and anticonvulsant activity

Published:2009 Issue:1 Volume:63 Page:17-31
ISSN:0367-598X
Container-title:Chemical Industry
language:en
Short-container-title:Hem Ind

Author:

Trisovic Nemanja¹^ORCID,Uscumlic Gordana¹,Petrovic Slobodan²

Affiliation:

1. Tehnološko-metalurški fakultet, Beograd

2. Tehnološko-metalurški fakultet, Beograd + Hemofarm koncern, Vršac

Abstract

Hydantoin is a five-membered cyclic ureide that is present in numerous biologically active compounds including antiarrhytmics, anticonvulsants and antitumor agents. This paper describes different ways of synthesis of hydantoin-derivatives, their physical properties and reactivity. Also, the most widely used hydantoin anticonvulsants and the analysis of structureactivity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here.

Publisher

National Library of Serbia

Subject

General Chemical Engineering,General Chemistry

Reference41 articles.

1. Synthesis and Structure−Activity Relationship Studies for Hydantoins and Analogues as Voltage-Gated Sodium Channel Ligands

2. Medicinal Chemistry of Neuronal Voltage-Gated Sodium Channel Blockers

3. The structure of hydantoins in solution and in the solid state

4. Hydantoins as antitumor agents

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