Affiliation:
1. Faculty of Technology, Leskovac
2. ICTM, Department of Chemistry, Belgrade
Abstract
A media consisting of isatin-Schiff bases and its inclusion complexes with
?-cyclodextrine was developed to maximize the production of antibiotics
Hexaene H-85 and Azalomycine ? by Streptomyces hygroscopicus CH-7. The media
with ?-cyclodextrine inclusion complex of isatin-3-thiosemicarbazone
resulted in the maximum antibiotics concentration of 493 ?g/cm3 for Hexaene
H-85 and 191 ?g/cm3 for Azalomycine B. The production of Hexaene H-85 and
Azalomycine is higher when ?-cyclodextrine complex is added as a nitrogen
source, comparing to pure isatin-Schiff base. The maximum concentration of
hexaene H-85 in medium with inclusion complex of isatin-Schiff base is
1.4-2.3 times higher than the basal medium. The maximum production of
Azalomycine is 2.1-3.4 times higher in media with inclusion complex of
Schiff base. During the fermentation process, the nutrient media with
?-cyclodextrine inclusion complexes with isatin-Schiff bases affect the
strain morphology, since it is in the form of compact pellets, which are
formed from short and long, branched filaments
Funder
Ministry of Education, Science and Technological Development of the Republic of Serbia
Publisher
National Library of Serbia
Subject
General Chemical Engineering,General Chemistry
Cited by
2 articles.
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