The improved photostability of naproxen in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin-Reference-Cited by-同舟云学术

The improved photostability of naproxen in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin

Published:2015 Issue:4 Volume:69 Page:361-370
ISSN:0367-598X
Container-title:Chemical Industry
language:en
Short-container-title:Hem Ind

Author:

Ilic-Stojanovic Snezana¹^ORCID,Nikolic Vesna¹,Nikolic Ljubisa¹,Zdravkovic Aleksandar²,Kapor Agnes³,Popsavin Mirjana⁴^ORCID,Petrovic Slobodan⁵

Affiliation:

1. Faculty of Technology, Leskovac

2. College of Textile, Leskovac

3. Faculty of Sciences, Department of Physics, Novi Sad

4. Faculty of Sciences, Department of Chemistry, Novi Sad

5. Faculty of Technology and Metalurgy, Belgrade

Abstract

The aim of this work was the preparation of the inclusion complex of naproxen with 2-hydroxypropyl-?-cyclodextrin (HP-?-CD) in order to improve the physical and chemical properties of naproxen. The molecular inclusion complexes of naproxen with HP-?-CD were prepared by using the co-precipitation method in the solid state with the molar ratio of 1:1. The structure of the obtained complex was characterized by using FTIR, 1H NMR, UV-Vis and XRD methods. The testing of naproxen photostability by the UV-Vis method indicated the degradation to aromatic ketone, 2-acetyl-6-methoxynaphthalene. FTIR analysis showed that the degradation started 15 days after the exposure of naproxen to daylight while the inclusion complex of naproxen: 2-hydroxypropyl-?-cyclodextrin was photostable for a period of 30 days.

Funder

Ministry of Education, Science and Technological Development of the Republic of Serbia

Publisher

National Library of Serbia

Subject

General Chemical Engineering,General Chemistry

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