Synthesis and characterization of Fe3O4/PEG-400/oxalic acid magnetic nanoparticles as a heterogeneous catalyst for the synthesis of pyrrolin-2-ones derivatives

Abstract

In this study, oxalic acid was successfully loaded onto Fe3O4/PEG-400 under ultrasonic irradiation and Fe3O4/PEG/oxalic acid as a new nanomagnetic catalyst was synthesized. The chemical structure of the catalyst was investigated by the FT-IR, XRD, EDX and SEM methods. The catalyst was used for the synthesis of 3-acyl-5-hydroxy-3-pyrrolin-2-one derivatives from the corresponding aldehydes, anilines and dimethyl acetylenedicarboxylate (DMAD) by a one-pot and three-component MCR reaction in the excellent yields (90?95 %) of products within 24 h at room temperature. Fourteen samples are available. The recovered catalyst could be satisfactorily used for a second and third run without regeneration. This method has a green and eco-friendly profile. In addition, this research introduces an improved mechanism for these types of reaction. The chemical structures of new compounds was characterized by their FT-IR, 1H-NMR, 13C- -NMR and mass spectra.