Some details on the method for measuring activity changes of neuronal populations

Author:

Kalauzi Aleksandar1ORCID,Spasic Sladjana1,Culic Milka2

Affiliation:

1. Centar za multidisciplinarne studije, Univerzitet u Beogradu, Srbija i Crna Gora

2. Institut za biološka istraživanja 'Siniša Stanković', Beograd, Srbija i Crna Gora

Abstract

Simple, complex action potentials (AP) and interspike recorded background activity (RBA) were detected and extracted from 12 rat cerebellar cortical recordings. For each recording, an averaged simple action potential (SAP) was formed. Fourier amplitude spectra of SAP and RBA were similar in all recordings. For one of the recordings, a series of RBA simulations (SBA) was generated, superimposing random SAPs, varying the superposition frequency (fsup). Average Fourier amplitude, Amp(SBA), was calculated, in order to use Amp(SBA)=f(fsup) as a calibration line for reading fsup of RBA, which is a measure of the population activity. A probability distribution for SAP intensities was derived and a family of calibration lines constructed. As all lines were linear and parallel (slope S) in log-log plots, a population activity change could be calculated as fsup2/fsup1=[Amp2(RBA)/Amp(RBA)]1/S.

Publisher

National Library of Serbia

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

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