Sulfur containing activated hydantions. Synthesis and screening some novel benzylidenehydantoins amino acids derivatives
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Published:2001
Issue:1
Volume:66
Page:17-21
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ISSN:0352-5139
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Container-title:Journal of the Serbian Chemical Society
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language:en
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Short-container-title:JSCS
Affiliation:
1. Al-Azhar University, Faculty of Science, Chemistry Department, Cairo, Egypt
Abstract
5-Benzylidenehydantoin reacts with chlorosulfonic acid to give the
corresponding p-sulfonyl chloride 1. Condensation with nucleophiles gives
amino acid derivatives 2-7. Coupling reactions of some amino acid
derivatives (2-6) with amino acid methyl ester hydrochloride in THF-Et3N
medium using the dicyclohexylcarbodiimide method (DCC) furnish the desired
dipeptidemethyl esters 8-12. The spectral data of the synthesized compounds
are briefly discussed.
Publisher
National Library of Serbia
Subject
General Chemistry
Cited by
1 articles.
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1. Chlorosulfonic Acid;Encyclopedia of Reagents for Organic Synthesis;2008-03-14