Microwave-assisted synthesis of azepines via nucleophilic aromatic substitution

Abstract

A novel and efficient route has been developed to afford 5H-dipyridoazepine derivatives from primary amines and 3,3'-(Z)-ethene-1,2-di-ylbis(4-chloropyridine). The procedure based on the double nucleophilic aromatic substitution provides a valuable synthetic tool for the synthesis of dipyridoazepines. The reaction proceeds without catalyst, under microwave irradiation condition.