Affiliation:
1. Department of Physical Chemistry, Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland
Abstract
The solubilities of five sparingly soluble drug-compounds in water have been
measured at constant temperatures (298.1K and 310.1K) by the classical
saturation shake-flask method. All substances presented in this work are
derivatives of anthranilic acid: flufenamic acid, (FLU), mefenamic acid,
(MEF), niflumic acid, (NIF), diclofenac sodium, (DIC), and meclofenamic
sodium, (MEC). All of them have anti-inflammatory action. Since the aqueous
solubility of the ionized drug is significantly higher than the unionized,
the experimental conditions that affect equilibrium solubility values such as
composition of aqueous buffer have been examined. The Henderson-Hasselbalch
(HH) relationship has been used to predict the pH-dependent solubility
profiles of chosen drugs at two temperatures. For this purpose the pKa values
of the investigated drugs have been determined with Bates-Schwarzenbach
spectrophotometric method at temperature 310.1 K. At temperature 298.1K these
values were reported earlier. Similar values of pKa were obtained from the
solubility measurements.
Publisher
National Library of Serbia
Subject
General Chemical Engineering
Cited by
50 articles.
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