Synthesis and antimicrobial, antifungal and anthelmintic activities of 3h-1,5-benzodiazepine derivatives-Reference-Cited by-同舟云学术

Synthesis and antimicrobial, antifungal and anthelmintic activities of 3h-1,5-benzodiazepine derivatives

Published:2008 Issue:10 Volume:73 Page:937-943
ISSN:0352-5139
Container-title:Journal of the Serbian Chemical Society
language:en
Short-container-title:JSCS

Author:

Kumar Rajesh¹,Joshi Y.C.¹

Affiliation:

1. Department of Chemistry, University of Rajasthan, Jaipur, India

Abstract

The diazonium salt of 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide in the presence of sodium hydroxide was condensed with different ?-diketones/?-ketoesters, 3a-e, to obtain new ?-diketones/?-ketoesters, 4a-e. The ?-diketones/?-ketoesters 4a-e were condensed with o-phenylenediamine (o-PDA) in presence of p-toluenesulfonic acid/SiO2 to give biologically active 3H-1,5-benzodiazepines, 5a-e. All the newly synthesized compounds were characterized by elemental analysis and spectral studies. The compounds 5a-e were screened for their antimicrobial, antifungal and anthelmintic activities.

Publisher

National Library of Serbia

Subject

General Chemistry

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