Alkylation of N-substituted 2-phenylacetamides: Benzylation of N-(4-chlorophenyl)-2-phenylacetamide-Reference-Cited by-同舟云学术

Alkylation of N-substituted 2-phenylacetamides: Benzylation of N-(4-chlorophenyl)-2-phenylacetamide

Published:2004 Issue:2 Volume:69 Page:85-92
ISSN:0352-5139
Container-title:Journal of the Serbian Chemical Society
language:en
Short-container-title:JSCS

Author:

Mijin Dusan¹^ORCID,Jankovic Vida¹,Petrovic Slobodan²

Affiliation:

1. Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, P. O. Box 3503, 11001 Belgrade, Serbia and Montenegro

2. Hemofarm Group, Beogradski put bb, 26300 Vršac, Serbia and Montenegro

Abstract

Benzylation of N-(4-chlorophenyl)-2-phenylacetamidewith benzyl chloride in the presence of powdered potassium hydroxide under various reaction conditions was performed in order to establish the possible reaction products. Different temperatures and ratios of reactants and solvents were used. The reactions were also carried out in the presence of different phase-transfer catalysts in toluene as a solvent. The formation of the reaction products was followed using gas chromatography. On the basis of the obtained results, the reactivity and the orientation in the alkylation reaction of the investigated amide is discussed.

Publisher

National Library of Serbia

Subject

General Chemistry

Reference4 articles.

1. Alkylation of N-substituted 2-phenylacetamides: Benzylation of N-(4-nitrophenyl)-2-phenylacetamide

2. Hydroxide Ion Initiated Reactions Under Phase Transfer Catalysis Conditions: Mechanism and Implications. New Synthetic Methods (62)

3. THE BEHAVIOR OF PHENYLACETONITRILE AND ALPHAPHENYLBUTYRONITRILE WITH SODIUM ETHYLATE1

4. THE PREPARATION OF PARA-UREIDO-PHENYLACETYLUREA, AND RELATED COMPOUNDS.

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