Affiliation:
1. Klinika za radiološku onkologiju i dijagnostiku, Služba radioterapije, Institut za onkologiju i radiologiju Srbije, Beograd
2. Institut za urologiju, Klinički Centar Srbije, Beograd
Abstract
Numerous questions regarding combined hormono-radiotherapy in the treatment of locally advanced prostate cancer still remain open. We present results of combined treatment in 133 our patients with locally advanced prostate cancer. All patients received hormonotherapy as neoadjuvant, concomitant with radiotherapy (tumor dose range 65-72Gy), and adjuvant. In six months follow-up time, complete regression (CR) was noted in 120 patients (90%), partial regression (PR) in 6 (4,5%), stabile disease (SD) in 2 (1,5%) and progression of disease (PD) in 5 patients (4%). In mean follow up time of 17 months (6-77), 13 patients relapsed. Five-year time to progression was 70%. Five-year disease-free interval for CR patients was 70%. At the date of last control CR was noted in 116 patients (87%), PR in 2 patients (2%), SD in 7 patients (5%), and 8 patients (6%) had progressive disease. Second malignancy was noted in 4 patients. Multidisciplinary studies directed towards the optimisation of combined treatment are ongoing. There are no definitive conclusions.
Publisher
National Library of Serbia