Square-pyramidal mononuclear, dinuclear and polymeric copper(II) complexes with (2-pyridinylmethyl)amino derivatives

Abstract

The coordination behavior of three ligand precursors 2-[(2-pyridinylmethyl) amino]acetic acid hydrochloride, 4-[(2-pyridinylmethyl)amino]benzoic acid hydrochloride and 4-{[2-(pyridin-2-ylmethylamino)ethylamino]methyl}- benzoic acid hydrochloride, HL1?HCl?HL3?HCl, respectively, in copper(II) complexes is described. The complexes were characterized by elemental analysis, ESI mass spectrometry and IR spectroscopy, as well as X-ray structural analysis. The reaction of copper(II) with HL1?HCl in methanol afforded the polymeric complex [{Cu(?-Cl)2(MeL1-?2N,N?)}n] (1) featuring the methyl ester of L1 (MeL1). With HL2?HCl or HL3?HCl, the dimeric complex [{CuCl(?-Cl)(HL2-?2N,N?)}2] (2) or the mononuclear complex [CuCl2(HL3- ?3N,N?,N??)] (3) were obtained. All complexes exhibited square-pyramidal geometries. In 1, polymeric chains are formed through bridging chlorido ligands without typical hydrogen bonding interaction. Contrarily, the COOH group in 2 is participating in the formation of intermolecular hydrogen bonding forming a supramolecular structure. In 3, intermolecular hydrogen bonding (Cl???H(O)) leads to a 1-D polymeric structure. The copper(II) complex 2 diminished viability of human 8505C, MCF-7, 518A2 and SW-480 cell lines. The tumoricidal effect of 2 was realized mainly through caspase-mediated apoptosis.