Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones-Reference-Cited by-同舟云学术

Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones

Published:2021 Issue:5 Volume:86 Page:459-468
ISSN:0352-5139
Container-title:Journal of the Serbian Chemical Society
language:en
Short-container-title:JSCS

Author:

Cobeljic Bozidar¹^ORCID,Zivkovic Marijana²^ORCID,Matic Ivana³^ORCID,Novakovic Irena²^ORCID,Sladic Dusan¹^ORCID,Andjelkovic Katarina¹,Krstic Natalija²^ORCID

Affiliation:

1. University of Belgrade, Faculty of Chemistry, Belgrade, Republic of Serbia

2. University of Belgrade, Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Belgrade, Republic of Serbia

3. Institute of Oncology and Radiology of Serbia, Belgrade, Republic of Serbia

Abstract

In this work, Pt(II) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized. The ligands and their metal complexes were studied by analytical and spectroscopic data (elemental analysis, IR, 1D-NMR and 2D-NMR, HSQC, HMBC, NOESY, COSY), the analysis of which enabled complete 1H and 13C assignments of each compound including E and Z isomers. All the synthesized ligands and complexes were screened for their cytotoxic and antimicrobial activity. The results demonstrate that the new steroidal thiosemicarbazone complexes were significantly less cytotoxic than the corresponding steroidal thiosemicarbazones. In addition, complexes showed lower antimicrobial activity than the standard drugs, similar to the activity of the starting thiosemicarbazones.

Funder

Ministry of Education, Science and Technological Development of the Republic of Serbia

Publisher

National Library of Serbia

Subject

General Chemistry