Synthesis of the 4’-desmethoxy analogue of RU79115-Reference-Cited by-同舟云学术

Synthesis of the 4’-desmethoxy analogue of RU79115

Published:2004 Issue:11 Volume:69 Page:855-859
ISSN:0352-5139
Container-title:Journal of the Serbian Chemical Society
language:en
Short-container-title:JSCS

Author:

Musicki Branislav¹,Periers Anne-Marie¹,Tessot Nicole¹,Klich Michel¹

Affiliation:

1. Medicinal Chemistry, Romainville Cedex, France

Abstract

The synthesis, and biological activity in vitro of the 4?-desmethoxy analogue (3) of RU 79115 (2) is described. Comparison of the biological activity of the two analogues clearly indicated the importance of the 4?-methoxy group in conferring good gyrase B inhibitory activity as well as antibacterial activity.

Publisher

National Library of Serbia

Subject

General Chemistry

Reference5 articles.

1. Improved antibacterial activities of coumarin antibiotics bearing 5′,5′-dialkylnoviose: biological activity of RU79115

2. DNA Gyrase Interaction with Coumarin-Based Inhibitors: The Role of the Hydroxybenzoate Isopentenyl Moiety and the 5‘-Methyl Group of the Noviose

3. Noviose mimics of the coumarin inhibitors of gyrase B

4. Synthesis and in vitro evaluation of novel highly potent coumarin inhibitors of gyrase B

5. High yield reduction of 2-O-trifluoromethanesulphonate esters of α-hydroxylactones to the corresponding 2-deoxylactones by lithium iodide trihydrate

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