Affiliation:
1. School of Medicine, Institute of Pathology, Niš
2. School of Medicine, Institute of Radiology, Niš
3. School of Medicine, Institute of Pathology, Kragujevac
Abstract
Introduction. Prostatic gland basal cell proliferations exhibit morphological
continuum ranging from basal cell hyperplasia to basal cell carcinoma. In the
following report, we described clinical features, morphological spectrum,
neuroendocrine differentiation and histogenesis of prostatic gland basal cell
carcinoma in our patient. Case report. Hematoxylineosin (HE), Alcian
blu-periodic acid schiff (ABPAS) at pH 2.5 stained sections and the
avidin-biotinperoxidase complex (ABC), were performed on prostate gland
paraffin-embedded tissue. Monoclonal antibodies directed against cytokeratin
(34?E12) which selectively stains basal cells, prostate specific antigen
(PSA), chromogranine A, neuron-specific enolase (NSE), synaptophysin and
CD56, were used. Basal cell proliferations exhibited a morphological
continuum ranging from basal cell hyperplasia to prostatic gland carcinoma.
In these prostatic lesions, positive reactivity was demonstrated for 34?E12
and CD56. These findings indicate that the basaloid cells of basal cell
hyperplasia, florid basal cell hyperplasia, atypical basal cell hyperplasia
and basal cell carcinoma are derived from basal cells of the normal prostate
gland suggesting a continuum in the progression of hyperplasia to benign and
then malignant neoplasia. The presence of CD56 protein in the discovered
lesions may be related to their neuroendocrine differentiation. Conclusion.
The fact, that our patient was well six years after the radical prostatectomy
supports the belief of some authors that basal cell carcinoma represents a
low grade carcinoma with an excellent prognosis.
Publisher
National Library of Serbia
Subject
Pharmacology (medical),General Medicine