Anticancer acitivity of Schiff base ligand(E)-4-((5-chloro-2 hydroxybenzylidene) amino)-1, 5-dimethyl-2-phenyl-1H-pyrazol-3(2H)- one and its Co(II), Cu(II) and Zn(II) metal complexes

Abstract

A series of transition metal complexes of Mn(II),Co(II), Ni(II), Cu(II), Zn(II) and VO(II) has been prepared by using the Schiff base ligand (L) derived from 4-aminoantipyrine and 5-chlorosalicylaldehyde. The structural properties of Schiff base ligand have been characterized by Mass, FT-IR, UV-VIS, 1H NMR spectroscopy etc. as well as metal complexes also studied by P-XRD, elemental analyses, thermogravimetric studies and various biological activities. The micro analytical data shows that, the metal complexes has been found to be 1:1 stoichiometry composition of M:L. Generally, it is observed that prepared metal complexes shows better antifungal, antibacterial, anticancer activities than its Schiff base ligand.