Survival analysis of patients with rare tumors of the uterine corpus – carcinosarcoma

Abstract

Background/Aim. Carcinosarcoma of the uterus, formerly known as malignant mixed M?llerian tumor, is a rare, aggressive malignancy of the female genital tract. The aim of this study was to analyse most important clinical and pathohistological characteristics of carcinosarcomas on operated patients, as well as to determine which of those factors are affecting disease free survival and overall survival of patients. Methods. The study was conducted as a retrospective analysis of medical data documentation of patients with a diagnosis of carcinosarcoma of the uterus who were surgically treated at Department of Gynecology, Clinic for Operative Oncology, Oncology Institute of Vojvodina, Sremska Kamenica, Serbia, in a period of 10 years, from the beginning of 2009 to the end of 2018. Results. The analysis included data for a total of 31 patients. Of all the examined parameters (age of the patient, clinical stage of the disease, histological grade, depth of myometrial invasion and lymphovascular invasion) the greatest influence on the choice of therapeutic procedure had a histological tumor grade. Conclusion. Our research showed the joint influence of the examined clinical and pathohistological factors parameters on progressionfree survival (PFS) and overall survival (OS) of patients with carcinosarcoma of the uterus. The only independent parameter that showed statistically significant impact on survival is lymphovascular invasion.