Diffuse osteolytic lesions in leukemic transformation of myelofibrosis-Reference-Cited by-同舟云学术

Diffuse osteolytic lesions in leukemic transformation of myelofibrosis

Published:2007 Issue:1-2 Volume:15 Page:45-47
ISSN:0354-7310
Container-title:Archive of Oncology
language:en
Short-container-title:Arch Oncol

Author:

Jurisic Vladimir¹^ORCID,Colovic Natasa²,Pavlovic Sonja³,Colovic Milica²

Affiliation:

1. Institute of Hematology, University Clinical Center, Belgrade, + School of Medicine, Kragujevac

2. Institute of Hematology, University Clinical Center, Belgrade

3. Institute for Molecular Biology and Genetic Engineering, Belgrade

Abstract

Myelofibrosis is a clonal myeloproliferative disorder characterized by splenomegaly, abnormal deposition of reticulin and collagen in the bone marrow, extramedullary hematopoiesis, dacryocytosis and leukoerythroblastic blood smear. Development and sustainment of fibrosis are mediated by complex network of several cytokines. Osteosclerosis is the most frequently observed bone change in myelofibrosis. We present an atypical case of leukemic transformation in myelofibrosis associated with diffuse osteolytic lesions and extremely elevated lactate dehydrogenase in serum, which indicates high bone turnover during leukemic infiltration and bone destruction.

Publisher

National Library of Serbia

Subject

Oncology,Hematology

Reference11 articles.

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2. Aberrant expression of transforming growth factor β-1 (TGFβ-1) per se does not discriminate fibrotic from non-fibrotic chronic myeloproliferative disorders

3. Etanercept, a soluble tumor necrosis factor receptor, palliates constitutional symptoms in patients with myelofibrosis with myeloid metaplasia: results of a pilot study

4. Effect of TNF-α on Raji cells at different cellular levels estimated by various methods

5. Correlation of Sera TNF-α with Percentage of Bone Marrow Plasma Cells, LDH, β2-Microglobulin, and Clinical Stage in Multiple Myeloma

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