Predictive value of inflammation and myocardial necrosis markers in acute coronary syndrome

Abstract

Introduction. Biochemical cardiac markers play an important role in diagnosing and treatment of patients with acute coronary syndrome. Markers of myocytes necrosis, troponins, have been recommended for diagnosing and treatment of myocardial infarction with ST segment elevation, myocardial infarction without ST segment elevation and unstable angina pectoris. Two more groups of cardiac markers have been gaining in importance: inflammation markers and cardiac function markers. The objective of this study was the risk stratification and identification of patients with coronary syndrome, who could take advantage from evolutionary changes of serum cardiac markers. Material and Methods. The method of the analysis sums up the results of independently published studies and literature and data base review, such as MEDLINE, PubMed and KOBSON. Inflammation markers. Systemic and localized inflammation plays an important role in the development of acute coronary syndrome. The following inflammation markers are available: C-reactive protein. IL-2, sedimentation of erythrocytes and fibrinogen; as well as myocardial necrosis markers: creatine kinase MB, myoglobin and cardiac troponins. Conclusion. Tropinins are ideal markers which enable early detection of patients with acute coronary syndrome, whereas inflammation markers are helpful in diagnosing and assessing the severity of inflammation.