Vaccination - a dilemma for a pediatric anesthesiologist: When is the right moment?

Author:

Stevanovic Vesna1ORCID,Kovacevic Gordana1,Bobos Marina2ORCID,Stevanovic Predrag3ORCID

Affiliation:

1. Dr Vukan Čupić Mother and Child Health Care Institute of Serbia, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, Serbia

2. Dr Dragiša Mišović - Dedinje Clinical Hospital Center, Belgrade, Serbia

3. University of Belgrade, Faculty of Medicine, Belgrade, Serbia + Dr Dragiša Mišović - Dedinje Clinical Hospital Center, Belgrade, Serbia

Abstract

Possible immune system interactions due to vaccination and drugs used in general anesthesia represent a dilemma for pediatric anesthesiologists in everyday practice. Immunosuppression caused by anesthesia and surgical trauma can affect the immunization process and cause-specific unwanted reactions. On the other hand, side effects due to vaccination can confuse clinicians in the immediate postoperative course. Both the nature of the vaccine and the type of surgery determines the delay period of elective surgical intervention. This current topic aims to present the scientific facts about the complex interactions between vaccination, immunization, general anesthesia, and surgical trauma and to provide recommendations for preoperative preparation.

Publisher

National Library of Serbia

Subject

General Medicine

Reference31 articles.

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2. Szakmany T. Anesthesia and immunomodulation: from basic science to clinical trials. Minerva Anestesiol. 2020;86(2):126-8. [DOI: 10.23736/S0375-9393.19.14327-1] [PMID: 32118383]

3. Herve C, Laupeze B, Del Giudice G, Didierlaurent AM, Tavares Da Silva F. The how’s and what’s of vaccine reactogenicity. NPJ Vaccines. 2019;4:39. [DOI: 10.1038/s41541-019-0132-6] [PMID: 31583123]

4. Vaccine Adverse Event Reporting System (VAERS). Center for Disease Control website. July 23, 2020 [Accessed July 30, 2020] Available at: https://www.cdc.gov/vaccinesafety/ensuringsafety/monitoring/vaers/index.html

5. American Academy of Pediatrics. Vaccination during hospitalization, including anesthesia and surgery. In: Kimberlin DW, Brady MT, Jackson MA, Long, SS, eds. Red Book: 2015 report of the committee on infectious diseases. American Academy of Pediatrics; 2015:98.

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