Terpenoids in four Inula species from Bulgaria

Author:

Trendafilova Antoaneta1ORCID,Ivanova Victoria1,Todorova Milka1,Staleva Plamena2,Aneva Ina3ORCID

Affiliation:

1. Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria

2. Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria + Sofia Tech Park, Laboratory for Extraction of Natural Products and Synthesis of Bioactive Compounds, Sofia, Bulgaria

3. Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences, Sofia, Bulgaria

Abstract

Phytochemical study of the chloroform extract of the aerial parts of Inula germanica L., I. ensifolia L., I. conyza (Griess.) DC. and I. salicina L. led to the identification of 33 terpenoids. ?- and ?-amyrin, lupeol, taraxasterol, ?-taraxasterol and their 3-O-acetates and 3-O-palmitates were identified by GC/MS. In addition, the structures of 3-O-palmitates of mainaladiol, arnidiol, faradiol and 16-hydroxylupeol were confirmed by NMR. ent-Kaur-16-en-19- -oic acid and its 15?-(3-methylpentanoyloxy) and 15?-(3-methylbutanoyloxy) derivatives were isolated from I. conyza. Ten closely related sesquiterpene lactones (germacranolides and melampolides) were found in I. germanica and their structural identification was performed by spectral analyses. I. ensifolia and I. salicina were free of sesquiterpene lactones and diterpenoids. All triterpenoids and diterpenoids, grazielia acid, desacetylovatifolin and 8-(2-methylbutanoyloxy)- 1(10),4,11(13)-germacrutrien-6,12-olide-14-oic acid are described for the first time in the studied species. The principal component analysis was used to find a relationship between th? investigated up to now Inula species, growing in Bulgaria.

Publisher

National Library of Serbia

Subject

General Chemistry

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