Affiliation:
1. Guru Jambheshwar University of Science & Technology, Department of Chemistry, Hisar, Haryana, India
2. Guru Jambheshwar University of Science & Technology, Department of Bio & Nano Technology, Hisar, Haryana, India
Abstract
In the present work, a series of twenty-four organotin (IV) complexes of the
type [R2SnLCl, R3SnL] have been synthesized by the condensation of
2-benzoylpyridine Schiff bases with R2SnCl2, R3SnCl (R= Me, n-Bu, Ph) in 1:1
molar ratio. These complexes were well characterized by IR, 1H, and 13C,
119Sn NMR, XRD and mass spectral techniques. In the search for biologically
more effective antimicrobial agents, all the synthesized ligands and
organotin complexes were evaluated for their in vitro antimicrobial
activities against two Gram positive and two Gram negative bacteria, and two
fungal strains by serial dilution method. The results of spectral data
revealed that the complexes formed were hexacoordinated with tridentate
ligands which coordinated through azomethine N, pyridine N and carboxylate O
ligation sites. The ligands on co-ordination with tin metal showed a
discernible augmentation in biocidal activity, however, the Ph and Bu
complexes were found to be more intoxicating. The results revealed that the
synthesized complexes were more noxious towards Gram positive strains as
compared to Gram negative strains which may be attributed to the presence of
an outer lipid membrane of lipopolysaccharides.
Publisher
National Library of Serbia
Cited by
19 articles.
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