Neonatal multisystem inflammatory syndrome during acute SARS-CoV-2 infection

Author:

Jaric Milica1,Katic Katarina2,Djuretic Andrea2,Stojanovic Vesna1ORCID,Milojkovic Milica1ORCID

Affiliation:

1. University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia

2. Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia

Abstract

Introduction. During the development and spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic, a new inflammatory response syndrome arose in newborns, defined as the multisystem inflammatory syndrome (MIS) in neonates (MIS-N). Case report. A term infant girl with a fever diagnosed with SARS-CoV-2 infection was admitted to the hospital. In laboratory findings, the values of lactate dehydrogenase, ferritin, interleukin-6, and D-dimer were elevated. Upon admission, dual parenteral antibiotic therapy (ceftazidime, vancomycin), and one day later, low molecular weight heparin (LMWH) therapy, was commenced. After five days of hospitalization and febrility, with negative results of microbiological analyses and further deterioration of laboratory findings, intravenous immuno-globulin (IVIg) was administered at a dose of 2 g/kg for one day and methylprednisolone at a dose of 1 mg/kg/day for four days, after which the reduction of corticosteroid therapy was continued with prednisone. One day after IVIg dministration, the newborn became afebrile, with the gradual normalization of laboratory findings. The newborn was discharged after 16 days of hospitalization. Ten days after discharge, prednisone therapy was discontinued. Two weeks after discharge, the administration of heparin was discontinued. Seven days later, the D-dimer value increased significantly, and the anticoagulant therapy was reinstated. After one month, the D-dimer value completely normalized, and the LMWH therapy was discontinued. Conclusion. After the applied therapy for MIS in children, there was a cessation of febrility and gradual normalization of values of the laboratory parameters. This confirms that the new-born, in this case, probably had MIS-N. The prolonged elevated D-dimer value was most probably a consequence of the MIS.

Publisher

National Library of Serbia

Subject

Pharmacology (medical)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3