Affiliation:
1. Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Belgrade
Abstract
The proposed method for the determination of fluocortolone is based on the
formation of a stable, yellow coloured hydrazone product with
1,4-dihydrazinophthalazine as the reagent. Heating at 85?C for 2 h was found
to be necessary to ensure optimal hydrazone formation in acidified
1-propanol as the solvent. The detection limit was 1.2 ?g/ml. This method
when applied for the determination of fluocortolone in pharmaceutical
formulations gave precise and reproducible results.
Publisher
National Library of Serbia
Cited by
1 articles.
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