Affiliation:
1. Kakatiya University, Department of Chemistry, Warangal, India
2. Indian Institute of Chemical Technology, Chemical Biology Laboratory, Hyderabad, India
Abstract
A convenient synthesis of novel1,4-disubstituted 1,2,3-triazoles (4a-j &
5a-j) is reported via copper (I) - catalyzed one pot [3+2] cycloaddition of
various alkyl halides, sodium azide with (prop-2-yn-1-yl)thiomorpholine and
4-(prop-2-yn-1-yl)thiomorpholine 1,1-dioxide. All the synthesized compounds
were investigated for their antimicrobial activity. Compounds 4a, 4b, 4c, 4g,
5a and 5j against S.epidermidis, 4a, 5a and 5d against P. aeroginosa, 4a, 4b
and 4g against K.pneumoniae, 4b, 5a and 5d against S.aureus and 5b, 5e and 5j
against B.Subtilis have shown excellent antibacterial activity compared to
the standard drugs Penicillin and Streptomycin. Compounds 4c, 4e, 4f, 4j, 5c,
5d, 5g and 5j have registered moderate antifungal activity as compared with
standard drug Ampothericin-B.
Publisher
National Library of Serbia
Cited by
21 articles.
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