X chromosomal analysis in population genetics and forensic science: A mini review

Abstract

The human X chromosome analysis has been applied to decipher the genetic structure of populations for applications in medical genetics and for human identification, parentage analysis and kinship analysis. Although it has not been studied on vast level with regard to human populations with comparison to other of its counterparts like autosomal markers, Y chromosome and mtDNA yet it is important for great potential in studying oncology, various diseases and forensic science applications. In this mini review, a snapshot of X chromosomal properties as genetic marker has been entailed. The structure and potential multiplex oriented kits utilizing X chromosomal markers have been discussed. Moreover, concerns of different researchers over X chromosomal published data have been referred to point out need of analyzing X chromosomal markers to unravel their role in population genetics, medical genetics and human identification.