Efficiency of marketable decontamination agent and graphene oxide on 99mTc and 131I spillages in nuclear medicine department

Author:

Razab Mohammad1,Nawi Norazlina2,Sunaiwi Rosidah1,Noor An'amt3,Aziz Mohd4,Hadzuan Fara1,Ibrahim Fathirah1,Khaizul Ahmad5,Abdullah Nor3

Affiliation:

1. Medical Radiation Programme, School of Health Sciences, University of Sains Malaysia, Kubang Kerian, Kelantan, Malaysia

2. Department of Nuclear Medicine, Radiotherapy and Oncology, School of Medical Sciences, University of Sains Malaysia, Kubang Kerian, Kelantan, Malaysia

3. Advanced Materials Research Cluster, Faculty of Bioengineering and Technology, University of Malaysia Kelantan, Jeli, Kelantan, Malaysia

4. Oncological and Radiological Sciences Cluster, Advanced Medical and Dental Institute, University of Sains Malaysia, Bertam, Kepala Batas, Pulau Pinang, Malaysia

5. Medical Radiation Programme, School of Health Sciences, University of Sains Malaysia, Kubang Kerian, Kelantan, Malaysia + Department of Nuclear Medicine, Radiotherapy and Oncology, School of Medical Sciences, University of Sains Malaysia, Kubang Kerian, Kelantan, Malaysia

Abstract

Dealing with open sources of radioactive substances in nuclear medicine is a daily task since contamination due to radioactive spills may happen frequently. Proper and safe decontamination management is a vital procedure. However, regular purchase of decontamination agents incurs high costs and might be toxic due to their chemical properties. The purpose of this study is to compare graphene oxide, which is an environmentally friendly carbon-based material and marketable decontamination agent, in decontaminating radioactive spillage. Samples of pure 99mTc and 131I from the laboratory were spilled on a petri dish. The spill was immediately decontaminated with a marketable decontamination agent swab and varying concentrations of graphene oxide swab. The initial radioactivity of each swab containing 99mTc and 131I was measured using a dose calibrator. The absorbance spectra of each sample were analysed using an ultraviolet-visible spectrophotometer. The morphology image of graphene oxide was observed under field emission scanning electron microscope. For decontamination using a marketable decontamination agent, the radioactivity of 131I was slightly higher, whereas that of 99mTc was slightly lower than the high concentration of graphene oxide. The absorbance spectra of 99mTc and 131I that had been decontaminated using graphene oxide were observed at a range of 200 nm to 250 nm due ???* to the transition.

Publisher

National Library of Serbia

Subject

Safety, Risk, Reliability and Quality,Nuclear Energy and Engineering

Reference23 articles.

1. Nawi, N. M., et al., Correlation of External Dose Rate with Whole Body Clearance Estimation in Radioiodine Therapy for rhTSH and THW Patients, Journal of Radiation Research and Applied Scineces, 13 (2020), 1, pp. 240-245

2. Akgun, E., et al., Therapeutic Applications of Radiopharmaceuticals: An Overview, Fabad Journal of Pharmaceutical Sciences, 46 (2021), 1, pp. 93-104

3. ***, Opportunities and Approaches for Supplying Molybdenum-99 and Associated Medical Isotopes to Global Markets, The National Academies Press, Washington, 2018, pp. 1-8

4. ***, Technetium-99m, StatPearls, Treasure Island, 2021, pp. 1-13

5. Wong, K. K., et al., Efficacy of Radioactive Iodine Treatment of Graves' Hyperthyroidism Using A Single Calculated 131I dose, Clinical Diabetes and Endocrinology, 4 (2018), 20, pp. 1-8

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