Affiliation:
1. The Pennsylvania State University, The Milton S. Hershey Medical Center, Department of Biochemistry and Molecular Biology, Hershey, USA
Abstract
A general method for the synthesis of higher sugars that can be used as
precursors for the synthesis of polyhydroxylated macrocyclic lactones
(macrolides) was described. The extension of the carbohydrate chain of a
hexopyranose was effected at its C(6) hydroxymethyl carbon by coupling of
two carbohydrate precursors via Wittig reaction. In this way
6,7-dideoxy-2,3,4,5,8,9,10-hepta-O-methyl-11-O-triphenylmethyl-D-arabino-D-glucoundecanose diethyl dithioacetal (1) was synthesized as
a model compound.
Publisher
National Library of Serbia
Cited by
1 articles.
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