Affiliation:
1. Department of Chemistry, Meerut College, Meerut, India
Abstract
A series of novel binuclear transition metal complexes was synthesized by
reaction of a Schiff base ligand
(1-Methyl-2-(2-oxo-1,2-dihydro-pyrimidin-4-ylimino)-propylideneamino-acetic
acid) (LaH) derived from 4-amino-pyrimidine-2-one, diacetyl, glycine and
corresponding chloride salt of Cu(II), Ni(II), Co(II) and Zn(II) metals in
1:1 (metal : ligand) molar ratio. The compounds were characterized by
elemental analyses, molar conductance measurement, magnetic moment
measurement and various spectral studies viz. IR, UV-visible, 1H-NMR,
13C-NMR, EPR and ESI-MS. Molar conductance measurement data revealed
non-electrolytic nature of metal complexes. Electronic absorption spectral
data, electronic paramagnetic resonance parameters and magnetic moment values
revealed an octahedral geometry for binuclear metal complexes. Cyclic
voltammetric study of Ni(II) complex shows a couple of one electron anodic
responses near 0.70 V and 1.10 V. In vitro biological activity of Schiff base
ligand and binuclear complexes has been checked against bacteria
(Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Salmonella
typhi) and fungi (Candida albicans and Candida parapsilosis) to assess their
antibacterial and antifungal properties.
Publisher
National Library of Serbia
Cited by
17 articles.
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