Effect of protamine sulfate on the isolated mesenteric arteries of normotensive and spontaneously hypertensive rats-Reference-Cited by-同舟云学术

Effect of protamine sulfate on the isolated mesenteric arteries of normotensive and spontaneously hypertensive rats

Published:2008 Issue:2 Volume:60 Page:163-168
ISSN:0354-4664
Container-title:Archives of Biological Sciences
language:en
Short-container-title:ARCH BIOL SCI BELGRA

Author:

Orescanin-Dusic Zorana¹,Milovanovic S.²,Spasic M.³,Radojicic R.⁴,Blagojevic D.¹

Affiliation:

1. Laboratorija za fiziologiju, Institut za biološka istraživanja 'Siniša Stanković', Beograd

2. Medicinski fakultet, Univerzitet u Istočnom Sarajevu, Foča, Bosna i Hercegovina

3. Laboratorija za fiziologiju, Institut za biološka istraživanja 'Siniša Stanković', Beograd + Hemijski fakultet, Beograd

4. Laboratorija za fiziologiju, Institut za biološka istraživanja 'Siniša Stanković', Beograd, + Biološki fakultet, Beograd

Abstract

We tested the relaxant effect of increased protamine sulfate (PS) amounts (10, 20, 50, 100 and 150 ?g/ml) on the isolated mesenteric arteries of normotensive and spontaneously hypertensive (SH) rats, with or without endothelium. PS caused concentration-dependent relaxation of isolated mesenteric arteries in both types of rats. The relaxation effect of PS was lower in SH rats than in normotensive ones. Our results indicate that the vascular smooth muscles play a significant role in PS-mediated relaxation.

Publisher

National Library of Serbia

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

Reference8 articles.

1. Different effects of protamine on canine coronary microvessel and conductance arteries: Evidence of hyperpolarizing factor release

2. Effect of MnSOD (E. coli) on the relaxation caused by sodium nitroprusside on isolated rat renal artery

3. Protamines and male infertility

4. Protamine induces vasorelaxation of human internal thoracic artery by endothelial NO-synthase pathway

5. Protamine is a low molecular weight polycationic amine that produces actions on cardiac muscle

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