Non-specific biological markers as a screening test for diagnostic of extrapulmonary tuberculosis
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Published:2012
Issue:2
Volume:64
Page:489-495
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ISSN:0354-4664
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Container-title:Archives of Biological Sciences
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language:en
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Short-container-title:ARCH BIOL SCI BELGRA
Author:
Stevanovic G.1,
Pelemis M.1,
Pelemis S.2,
Pavlovic M.1
Affiliation:
1. Belgrade Medical Faculty, Clinic for Infectious and Tropical Diseases, Belgrade
2. Clinic for Otorhinolaryngology, Clinical Center of Serbia, Belgrade
Abstract
Serum concentrations of adenosine deaminase were determined in 223 febrile
patients. In 62, we discovered extrapulmonary tuberculosis. Serum levels of
immunoglobulin G were monitored in 287 febrile patients, and 68 had
extra-pulmonary tuberculosis. Serum concentrations of adenosine deaminase
were significantly higher in patients with tuberculosis compared to other
patients with fever of unknown origin. Serum concentrations declined during
antituberculosis therapy. A correlation with the localization of infection
was not found. Levels of immunoglobulin G were higher in patients with
tuberculosis. Both tests had high sensitivity and specificity and could
therefore be used for screening extrapulmonary tuberculosis; however, they
can only be interpreted adequately following a full clinical investigation.
Publisher
National Library of Serbia
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology
Cited by
1 articles.
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