Affiliation:
1. Department of Physiology, “Gr. T. Popa” University of Medicine and Pharmacy, Iaşi, Romania
2. “Alexandru Ioan Cuza” University, Iaşi, Romania + Center of Biomedical Research of the Romanian Academy, Iaşi Branch, Iasi, Romania
Abstract
Several trace elements, including manganese (Mn), affect the cardiovascular
system and are implicated in some cardiovascular disease mechanisms. The
effects of Mn on the vascular system, such as in the control of blood flow
and blood pressure, are not completely understood. Thus, the main objective
of the present study was to determine the effects of a 45-day exposure to two
different doses of Mn on blood pressure values of male Wistar rats. Our
results showed a significant time effect (p<0.001, ANOVA, repeated measures)
on the values of blood pressure measurements during 45 days of Mn treatment
of rats with two doses (3 mg/kg/day and 10 mg/kg/day). Additionally, we
observed significant differences in the values of blood pressure
measurements, especially on days 2 (p<0.001), 9 (p<0.05), 24 (p<0.05), 28
(p<0.01) and 43 (p<0.05). Further studies are necessary in order to establish
the mechanism and relevance of Mn in this area of research. <br><br><font color="red"><b> This article has been retracted. Link to the retraction <u><a href="http://dx.doi.org/10.2298/ABS161021104E">10.2298/ABS161021104E</a><u></b></font>
Publisher
National Library of Serbia
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology
Cited by
2 articles.
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