Synthesis and antimycobacterial activity of novel heterocycles-Reference-Cited by-同舟云学术

Synthesis and antimycobacterial activity of novel heterocycles

Published:2007 Issue:1 Volume:72 Page:5-11
ISSN:0352-5139
Container-title:Journal of the Serbian Chemical Society
language:en
Short-container-title:JSCS

Author:

Yar Shahar¹,Siddiqui Ahmad¹,Ali Ashraf¹

Affiliation:

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi

Abstract

In the present investigation 4-hydroxy-3-methylacetophenone on condensation with various aromatic aldehydes in methanolic KOH solution yielded the corresponding chalcones (CI-CXI). These chalcones were further reacted with hydrazine hydrate in ethanol which led to the formation of pyrazoline derivatives (HI-HXI). The newly synthesized heterocyles were characterized on the basis of their chemical properties and spectroscopic data. All newly synthesized compounds were evaluated for their antimycobacterial activities against Mycobacterium tuberculosis H37Rv. .

Publisher

National Library of Serbia

Subject

General Chemistry

Reference7 articles.

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