Influence of ACE and ACTN3 genes polymorphisms on cardiovascular adaptation in female football players
Author:
Petrovic Tijana1ORCID, Zdravkovic Marija2ORCID, Djelic Marina3, Gavrilovic Tamara4, Mihailovic Zoran1, Atanasijevic Nikola1, Stojkovic Oliver1
Affiliation:
1. Institute of forensic medicine, Faculty of medicine, University of Belgrade, Belgrade, Serbia 2. University Hospital Medical Center “Bezanijska Kosa”, Faculty of medicine, University of Belgrade, Belgrade, Serbia 3. Institute of medical physiology, Faculty of medicine, University of Belgrade, Belgrade, Serbia 4. Serbian Institute of Sports and Sports Medicine, Belgrade, Serbia
Abstract
The aim of study was to investigate distribution of ACE and ACTN3 gene
polymorphisms in young female footballers and to test association of common
gene polymorphisms with body composition, arterial blood pressure and ECG
screening variables. A group of 45 white, healthy, adolescent female elite
footballers (FG) and 60 sedentary female controls (CG) enrolled in this
study. HRM method has been developed to differentiate between variant
alleles of ACE and ACTN3 genes. No significant difference was found in the
ACE and ACTN3 genotypes or allele frequencies distribution between FG and CG
(p>0.05). Also, neither insertion in the ACE gene, nor nonsense mutation in
the ACTN3 gene had a significant effect on resting BP and ECG parameters.
Cardiovascular adaptation to intensive physical activity in FG is manifested
as lowered resting systolic and diastolic blood pressure (lower 18 and 11
percentiles, respectively). Footballers with ACE DD and ACTN3 XX
polymorphisms had higher values of Sokolow-Lyon voltage for LV hypertrophy,
but without statistically significance (p=0.61 and 0.2, respectively).
Interpretation of the effect of specific genes with presumed large effect on
sport performance, should be cautious, especially in team sports with a
mixed type of physical activity, such as football.
Publisher
National Library of Serbia
Subject
Plant Science,Genetics
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