Affiliation:
1. Faculty of Medicine, Institute of Epidemiology, Belgrade
2. Public Health Center „Dr Simo Milošević“, Belgrade
3. Clinical Center of Serbia, Department of Gynecology and Obstretics, Belgrade
Abstract
Background/Aim. Ovarian cancer (OC) comprises 3% of all cancers, but it is
the fifth most common cause of cancer death in women. The aim of this
case-control study was to determine the risk factors for OC in the female
population of Belgrade, Serbia. Methods. A total of 80 consecutive patients
were enrolled in the study between 2006 and 2008 in two national referral
centers for OC in Serbia. The control subjects were recruited during the
regular gynecological check-ups in the Public Health Center of the
corresponding municipalities. All the study participants were interviewed
during their visits to the above mentioned institutions by two physicians
using the same questionnaire. In order to analyze the influence of specific
exposure to the risk of the disease, we categorized variables according to
the cut-off values. Odds ratios (OR) and 95% confidence intervals (95% CI)
were calculated separately for each variable using univariate conditional
logistic regression analysis. Results. There were no statistically
significant differences in educational level, years of schooling,
occupational and employment status between patients with OC and women in the
control group. Oral contraceptives use and other contraceptive methods
(condoms, mechanical contraceptive devices) were highly statistically
significantly more frequent among women in the control group (OR = 0.2, 95%
CI 0.1-0.7, p = 0.005; OR = 0.1, 95% CI 0.01-0.5, p = 0.001, respectively).
The patients with OC practiced sports for 6.3 ? 2.1 years, and controls for
11.8 ? 9.9 years. Sport and recreation activities were statistically
significantly protective (OR = 0.2, p = 0.011; OR = 0.4, p = 0.019). Tea
consumption on daily basis had a highly statistically significant protective
effect (OR = 0.3, p = 0.001). Conclusions. Oral contraceptives use and
physical activity were independent protective factors for OC in this study.
Publisher
National Library of Serbia
Subject
Pharmacology (medical),General Medicine
Cited by
8 articles.
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