Affiliation:
1. Faculty of Technology and Metallurgy, Belgrade
2. Research and Development Center, Beohemija Business Group, Belgrade
Abstract
Polyphenols are compound which are widely studied because of their
antioxidative and potential therapeutic properties. Systems for the
controlled release of drugs offer a number of benefits comparing with
traditional forms of medicines and because of that these systems are widely
researched. The objective of this paper is to investigate the possibility of
using liposomes as carriers of polyphenols and influence the membrane
composition on the release rate of encapsulated polyphenols. Experiments show
how the membrane modification affects the mass transfer comparing to a
conventional liposomes. Liposomes were modified with surfactants Tween 20 and
Tween 60, and thyme tea extract was used as a source of polyphenols. The
diffusion of polyphenols from thyme extract, dispersion of conventional
liposomes and liposomes modified with Tween 20 and Tween 60 was studied using
Franz diffusion cell. From the experimental data diffusion coefficients were
determined for each of the systems, as well as the corresponding diffusion
resistances. From the obtained results it can be concluded that the
encapsulation of polyphenols in liposomes significantly slows diffusion, and
with membrane modification can be achieved further slowing. The diffusion
resistance of the liposome membrane modified with Tween 20 and Tween 60 is
about 5 times higher compared to the diffusion of unencapsulated polyphenols
from the thyme extract.
Publisher
National Library of Serbia
Subject
General Chemical Engineering,General Chemistry
Cited by
9 articles.
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