Affiliation:
1. Faculty of Medical Sciences, Kragujevac
Abstract
The aim of the present study was to evaluate the subchronic effects of
3,4-methylenedioxymethamphetamine on several oxidative stress markers: index
of lipid peroxidation (ILP), superoxide dismutase (SOD) activity, superoxide
radical (O2.-) levels, and reduced glutathione (GSH) levels in the frontal
cortex, striatum and hippocampus of the rat. The study included 64 male
Wistar rats (200-250g). The animals were treated per os with of 5, 10, or 20
mg/kg of 3,4-methylenedioxymethamphetamine (MDMA) every day for 15 days. The
subchronic administration of MDMA resulted in an increase in ILP, SOD and
O2.-, and a decrease in GSH, from which we conclude that oxidative stress
was induced in rat brain.
Publisher
National Library of Serbia
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology