Affiliation:
1. Faculty of Science, Kragujevac
2. Vinča Institute of Nuclear Sciences, Belgrade
Abstract
The polydentate ligand,
3-[(2-hydroxy-benzylidene)-amino]-2-thioxo-imidazolidin-4-one, was
synthesized by intermolecular cyclocondensation reaction of
2-hydroxybenzaldehyde thiosemicarbazone and ethylchloroacetate. Novel
palladium(II) complex was obtained by nucleophilic substitution of both DMSO
ligands from cis-[Pd(DMSO)2Cl2] with iminic nitrogen and thiolactamic sulfur
from ligand. The structure of compounds was characterized on the basis of
their spectral data. The cytotoxic activity of the ligand and palladium(II)
complex was studied on tumor cell lines: human colon carcinoma HCT-116 and
SW-480 cells using MTT viability test. The results show that investigated
palladium(II) complex has significantly greater cytotoxic effect compared to
ligand.
Funder
Ministry of Education, Science and Technological Development of the Republic of Serbia
Publisher
National Library of Serbia
Cited by
11 articles.
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