Affiliation:
1. Blood Transfusion Institute of Vojvodina, Novi Sad + University of Novi Sad, Faculty of Medicine, Department of Transfusiology, Novi Sad
2. University of Novi Sad, Faculty of Medicine, Department of Nursing, Novi Sad
Abstract
Introduction. The ABO blood group antigens are determined by genes located at
three separate genetic loci. Loss or weakening of ABO antigens is often
associated with hematological malignant diseases, but also solid tumors in
the body. A change in the expression of ABO antigens leads to discrepancies
when determining the patient?s blood group and carries the risk of
incompatible transfusions. Case Report. During the blood typing of a
27-year-old female patient with a diagnosis of acute myeloid leukemia, there
were discrepancies in the interpretation of the ABO blood group. Since the
confirmation blood group indicated that it was blood group O, when
determining the reverse blood group, the reading showed the absence of the
expected agglutination of group A1 and B red blood cells. By examination of
the patient?s records, as well as confirmation genotyping, the blood group A
was established. After the patient entered the remission phase of the
disease, the A Rhesus D positive blood group was determined, without
discrepancies during testing. Conclusion. Changes in blood groups can occur
even before the diagnosis of hematological malignant disease is established.
For this reason, it is extremely important to thoroughly examine any
discrepancy during blood typing in order to provide patients with safe
blood.
Publisher
National Library of Serbia
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